从乡下来到城市的美纪（志尊淳饰）在时装公司工作，是一个从小就向往可爱女孩子生活的人，但他本身有一个大秘密——他是个“跨性别者”。美纪的生理性别是男性，外表却是华丽丽的女孩子。不过，他对男人没有兴趣，喜欢的是女性，总之是个复杂的人物。

某天，美纪遇到了同学后藤（町田启太饰）。老同学干生（美纪的原名）的样子让后藤有点晕，不过，两人因为意外事件不得不一起生活。就在这奇妙的共同生活中，美纪生活中的各种“日常”所潜藏的混乱让后藤吃惊，但是，美纪以压倒一切的自我肯定力勇敢地生活着。

Sex Change Hospital is an American six-part documentary series following trans men and women having genital reassignment surgeries. Dr. Marci Bowers performs the surgeries and calls upon her own experiences as a transgender woman to guide her patients as they go through the ultimate life changing procedure.

Even as a child, Lee knew she was different. The feeling of being born in the wrong body grew and after hiding her transsexuality for many years, the then TV carpenter had no choice – the body had to change in order for Lee to live.