For centuries, a secret Order of priests has existed within the Church. A renegade priest, Father Alex Bernier, is sent to Rome to investigate the mysterious death of one of the Order's most revered members. Following a series of strangely similar killings, Bernier launches an investigation that forces him to confront unimaginable evil.

A big-city female doctor returns to her roots in the backwoods of the Blue Ridge Mountains to bring modern medicine to the local folks in the Appalachia of the 1930s and finds herself at odds with the homespun ways of the resident medicine woman.