At a tiny Parisian café, the adorable yet painfully shy Amélie accidentally discovers a gift for helping others. Soon Amelie is spending her days as a matchmaker, guardian angel, and all-around do-gooder. But when she bumps into a handsome stranger, will she find the courage to become the star of her very own love story?

For young Parisian boy Antoine Doinel, life is one difficult situation after another. Surrounded by inconsiderate adults, including his neglectful parents, Antoine spends his days with his best friend, Rene, trying to plan for a better life. When one of their schemes goes awry, Antoine ends up in trouble with the law, leading to even more conflicts with unsympathetic authority figures.

Born into aristocracy, Toulouse-Lautrec moves to Paris to pursue his art as he hangs out at the Moulin Rouge where he feels like he fits in being a misfit among other misfits. Yet, because of the deformity of his legs from an accident, he believes he is never destined to experience the true love of a woman. But that lack of love in his life may change as he meets two women

Parisian nightclub owner Simone Pistache is known for her performances of the can-can, which attracts the ire of the self-righteous Judge Philipe Forrestier. He hatches a plot to photograph her in the act but ends up falling for her — much to the chagrin of her boyfriend, lawyer François Durnais.

Sometimes reduced to the image of a cursed artist, Amedeo Modigliani, an admirer of the masters of the Italian Renaissance, has traced an unparalleled path in modern art.