Amélie Poulain és una noia de 22 anys que ha crescut en una família força peculiar. Ara es guanya la vida fent de cambrera en un cafè de Montmartre. Amélie viu sola i busca l'amor i el sentit de la vida. Un dia troba una capsa plena de records d'infantesa amagada al seu pis i Amélie decideix buscar-ne el propietari i, d'aquesta manera, fer-lo feliç.

For young Parisian boy Antoine Doinel, life is one difficult situation after another. Surrounded by inconsiderate adults, including his neglectful parents, Antoine spends his days with his best friend, Rene, trying to plan for a better life. When one of their schemes goes awry, Antoine ends up in trouble with the law, leading to even more conflicts with unsympathetic authority figures.

París, segle XIX. El pintor impressionista Toulouse-Lautrec, tolit per un accident de la infància, s'apassiona per la vida bohèmia dels baixos fons i visita amb freqüència el mític Moulin Rouge, un cabaret on beu i contempla a les sensuals ballarines de can-can. L'artista coneix a una prostituta i comença amb ella una turbulenta relació sentimental.

Parisian nightclub owner Simone Pistache is known for her performances of the can-can, which attracts the ire of the self-righteous Judge Philipe Forrestier. He hatches a plot to photograph her in the act but ends up falling for her — much to the chagrin of her boyfriend, lawyer François Durnais.

Sometimes reduced to the image of a cursed artist, Amedeo Modigliani, an admirer of the masters of the Italian Renaissance, has traced an unparalleled path in modern art.