Katey Sagal esittää kolmen lapsen yksinhuoltaja Catea, joka miehensä kuoleman jälkeen koittaa yksin pärjätä kolmen teini-ikäisen lapsen pyörityksessä. Tukea antavat Caten isä ja Caten sukulaispoika CJ. .

Outspoken Kat Stratford couldn't be less like her sister, super sweet, yet kinda conformist Bianca. The only things they seem to have in common are being new at school and their overprotective dad.

Life with Boys is a Canadian teen sitcom that started broadcasting in Canada on YTV in September 2011. It follows Tess Foster as she copes with living in a home with just boys: her father, Jack, and three brothers, Gabe, Spencer and Sam. With the help of her best friend, Allie, she pulls through. Life with Boys is created by Michael Poryes, who also co-created Hannah Montana and That's So Raven.

It was announced that Life with Boys was renewed a second season. Shooting started on September 4, 2012, in Toronto. On February 6, 2013, the series premiered on American network TeenNick.