Pineapple Express ile havalarda uçun. Knocked Up isimli filmin yönetmeni ve senaristi olan Judd Apatow bu delicesine komik filmi bizlere sunuyor. Bir uyuşturucu patronu (Gary Cole) ve ona yardım eden rüşvetçi polis (Rosie Perez) tarafından işlenen cinayetin tek tanığı tembel bir keştir (Seth Rogen). Ölüm listesine girdiğinde, hayatı için kaçmaya başlar. Şaşkın torbacısını (James Franco) ve tedarikçisini (Danny McBride), kendisi ile beraber bu komik maceraya sürükler. Gordon Green tarafından yönetildi. Senaryosunu ise Seth Rogen ve Evan Goldberg yazdı.

Several lost-soul night-owls, including a nightclub owner, a talkback radio relationships counseller, and an itinerant stranger have encounters that expose their contradictions and anxieties about love and acceptance.

Nick Pearson is a life-long bachelor who is finally settling down. On the brink of his wedding he is surprised to find he has a 13 year old son who has come to find his him through the help of a psychic. The problem is Nick can't stand kids and would happily send the boy back to live with his biological mother, except that no one has any clue who that might be. Having nowhere to turn Nick must hit the road with the boy and the neurotic, inept psychic to track down dozens of his disgraced ex-flings to whom he must ask the awkward question - with very mixed results.

A divorced doctor finds himself in real trouble living with his daughter alone now. But fortunately a guardian angel is watching over the lives of both of them.