Дейл има конкретна причина да посещава своя мързелив дилър Сол и тя е да купува от него рядък сорт марихуана, който се казва Ананас Експрес. Един ден Дейл става свидетел на убийство, паникьосва се и оставя фас на местопрестъплението. Дейл вече има още един повод да се отбие при Сол, той иска да разбере дали наистина тази трева не се среща често и каква е вероятността цигарата да доведе до него. Параноята на двамата се оказва основателна и не е подсилена от пафкането, както си мислят. Лошите са по следите им и искат бързо да се отърват от тях.

Several lost-soul night-owls, including a nightclub owner, a talkback radio relationships counseller, and an itinerant stranger have encounters that expose their contradictions and anxieties about love and acceptance.

Nick Pearson is a life-long bachelor who is finally settling down. On the brink of his wedding he is surprised to find he has a 13 year old son who has come to find his him through the help of a psychic. The problem is Nick can't stand kids and would happily send the boy back to live with his biological mother, except that no one has any clue who that might be. Having nowhere to turn Nick must hit the road with the boy and the neurotic, inept psychic to track down dozens of his disgraced ex-flings to whom he must ask the awkward question - with very mixed results.

A divorced doctor finds himself in real trouble living with his daughter alone now. But fortunately a guardian angel is watching over the lives of both of them.