Homer is an orphan who was never adopted, becoming the favorite of orphanage director Dr. Larch. Dr. Larch imparts his full medical knowledge on Homer, who becomes a skilled, albeit unlicensed, physician. But Homer yearns for a self-chosen life outside the orphanage. What will Homer learn about life and love in the cider house? What of the destiny that Dr. Larch has planned for him?

When the Campbell family moves to upstate Connecticut, they soon learn that their charming Victorian home has a disturbing history: not only was the house a transformed funeral parlor where inconceivable acts occurred, but the owner's clairvoyant son Jonah served as a demonic messenger, providing a gateway for spiritual entities to crossover.

The story of the early, murderous roots of the cannibalistic killer, Hannibal Lecter – from his hard-scrabble Lithuanian childhood, where he witnesses the repulsive lengths to which hungry soldiers will go to satiate themselves, through his sojourn in France, where as a med student he hones his appetite for the kill.