Tânăra Emily primește în dar un pui de cățel roșcovan care se va dovedi un câine magic: cu cât este mai iubit, cu atât el crește mai mare, și mai mare. Nu va trece mult timp până când apartamentul de oraș în care locuiesc va deveni neîncăpător, iar fetița va porni în aventura vieții ei, însoțită de unchiul său trăznit.

Fearing that he costs too much to feed, Clifford decides to join a traveling carnival so he can enter a talent contest in hopes of winning a lifetime supply of Tummy Yummies treats. Joined by his friends Cleo and T-Bone, Clifford meets up with Shackleford the High-Flying Ferret and Rodrigo Chihuahua of Steel, as they work together to turn a broken-down act into a record-breaking show.

Lester and Orville accidentally launch a rocket which is supposed to fly to Mars. Instead it goes to New Orleans for Mardi Gras. They are then forced by bank robber Mugsy and his pal Harry to fly to Venus where they find a civilization made up entirely of women, men having been banished.