理查德博士（尤安•格瑞福德 Ioan Gruffudd 饰）的科学梦想即将实现！他将飞往宇宙风暴的中心，揭开人类基因的密码。同行的还有，项目赞助人冯•杜姆（朱利安•麦克马洪 Julian McMahon 饰）、宇航员本•格林姆（麦克•切克里斯 Michael Chiklis 饰）、博士的前女友苏•斯通（杰西卡•阿尔芭 Jessica Alba 饰）以及她弟弟约翰尼•斯通（克里斯•埃文斯 Chris Evans 饰）。
不料，飞船接近风暴中心时，由于计算错误，导致飞船被宇宙射线所吞没！大难逃生返回地球后，组员们的基因因宇宙射线的影响，发生了变异，他们具有了各个不同的超能力。
理查德、苏、约翰尼和本组成了“神奇四侠”，利用宇宙射线所赋予的超能力去打击黑暗势力、帮助世界。杜姆获得超能力后变身成为了“毁灭钢眼博士”，正在实施他的邪恶计划。神奇四侠出击了！
The Fantastic Four return to the big screen as a new and all powerful enemy threatens the Earth. The seemingly unstoppable 'Silver Surfer', but all is not what it seems and there are old and new enemies that pose a greater threat than the intrepid superheroes realize.
天才少年理查德（迈尔斯·特勒 Miles Teller 饰）凭借物体传送装置的发明得到正研究量子门的富兰克林•斯通的赏识，他将理查德招至麾下，通过和维克多（托比·凯贝尔 Toby Kebbell 饰）、约翰尼（迈克尔·B·乔丹 Michael B. Jordan 饰）、苏珊（凯特·玛拉 Kate Mara 饰）等才华横溢的青年们的通力合作，量子门的研究终于取得突破性进展。不久之后，不甘成果被政府攫取的年轻人们叫上理查德的朋友本（杰米·贝尔 Jamie Bell 饰），偷偷潜入那个未知的世界探险，谁知却被神秘的能量所感染。在此之后，他们拥有了身体伸缩、控制火焰、岩石化以及隐形等能力。
为了能过回复从前的样子，年轻人们再次走向量子门，而对面的世界还有一个当初被丢下的同伴等待着他们……
When dosed with cosmic rays, four intrepid astronauts are given incredible powers. They decide to form a superhero group called the Fantastic Four to fight their arch-enemy, Dr. Doom.
At 89 years old, Stan Lee's name appears on more than one BILLION comics in 75 countries in 25 languages. Arguably the most recognized name in comics, Stan Lee has co-created over 500 legendary pop culture characters including Spider-Man, Fantastic Four, X-Men, Iron Man, Thor and The Hulk. Stan continues to create new material and entertain fans of all ages with fantastic stories and characters in all areas of entertainment. With Great Power: the Stan Lee Story, explores the vivid life and imagination of Stan Lee, from the early days of his Depression-era upbringing through the Marvel Age of Comics and beyond! The film uncovers original transcripts, illustrations, photographs and stories of Lee's fascinating journey from his early years at Timely Comics and World War Two, the comic book industry's censorship battle of the 1950's led by Dr. Fredric Wertham, the dawn of Marvel Comics and the legendary characters Stan co-created, to his current company POW! Entertainment.
It's here - the longest running Marvel series in history arrives for the first time on DVD. Learn the origin of the Fantastic Four, and be there as Mr. Fantastic, The Invisible Woman, Human Torch and The Thing save the world from the dastardly Doctor Doom and his legion of villains. Now you can relive the action and excitement with 5 dynamic episodes from the popular 1990s animated series. It's fantastic compilation you'll want to experience over and over again.