Når to venner bestemmer seg for å prøve noe nytt, og bare nyte godt av fordelene ved den gjensidige tiltrekkingen uten noen som helst følelsesmessig innblanding, forstår de snart at stereotypene fra de romantiske komediene ikke bare er fri fantasi.

Giant lava breathing tarantulas – Lavalantulas – erupt out of ancient volcanos in the Santa Monica Mountains, raining death and destruction upon Los Angeles. With the City of Angels on the verge of incineration, only a washed up ‘90s action hero actor stands in the way of this monstrous swarm of bloodthirsty creatures who burn their victims alive.

Farm boy Daryl Cage's parents ship him off to the big city to live with his brother, hoping he will have a better life there. After a baggage mixup at the airport, Daryl finds himself in possession of a drug cache, which a ruthless drug dealer wants back. The dealer murders Daryl's brother and the small town boy ends up all alone in the big city, being pursued by both the drug dealer and the police, who suspect him of the murder.

Growing up in small-town America, two friends dream about escaping their confining families to search for their dreams and freedom in the big city. Arriving in Los Angeles, the two discover the harsh realities of the city as they enter the shadowy world of the film business. Ultimately, the two friends must choose between love and friendship and soon discover that life has its own destiny for everyone.

Larry Wessel presents darkest Hollywood and explores some of tinsel town's most grisly tragedies, including the murders of Sharon Tate and The Black Dahlia.