Melvin Udall, a cranky, bigoted, obsessive-compulsive writer of romantic fiction, is rude to everyone he meets, including his gay neighbor, Simon. After Simon is hospitalized, Melvin finds his life turned upside down when he has to look after Simon's dog. In addition, Carol, the only waitress at the local diner who will tolerate him, must leave work to care for her sick son, making it impossible for Melvin to eat breakfast.

Everyone hates Ward’s wife and wants her dead, Ward most of all. But when his friends’ murderous fantasies turn into an (accidental) reality, they have to deal with a whole new set of problems — like how to dispose of the body and still make their 3 p.m. tee time.