Hunden Bolt har så stor succes som superhelt i en tv-serie, at han tror, at han også har superhelteevner i virkeligheden. Ved en fejl havner han i New York, hvor han møder den forladte huskat Mittlens og den overvægtige hamster Rhino, der er helt vild med tv shows. De hjælper ham med at komme tilbage til Hollywood. Undervejs lærer Bolt, at man godt kan være en helt uden at have overnaturlige evner.
De er snu. De er listige. De udkæmper en tophemmelig, højteknologisk kamp om verdensherredømmet i al hemmelighed. De er katte og hunde. Se hvad der sker i denne storslåede beretning om den ekcentriske professor, der gør en opdagelse, som kan forrykke kæledyrenes magtbalance. En uerfaren ung Beagle-hvalp skal ud på den ultimative umulige mission, som går ud på at redde menneskeheden fra den totale kat-astofe!
Nobody's home, so Tom invites his alley cat friends in to look at home movies (clips from earlier cartoons where Tom gets the drop on Spike). While they're showing them, Spike sneaks in.
A cat-about-town fancies himself such an irresitible "hunk" he momentarily resembles Victor Mature. His wooing of a cute kitten gets derailed by a prankster dog using a cat hand puppet to trap him.
It's Christmas Day in the home of Granny, and her pet cat Sylvester delights at chasing her new Tweety Bird and takes fright at the bulldog unwrapped from under the tree.
A homeless cat (Claude Cat) searching for food is harassed by the playful antics and barking of an energetic pup (Frisky Puppy). Frisky repeatedly sneaks up behind the poor tabby cat (who hates the dog) and scares it into jumping vertically when it barks. After Claude finally silences the pup, he encounters a larger dog, whose bark has a disastrous effect. Tweety Bird has two lines. Can you guess what they are?