Uma equipa de filmagens liderada pelo realizador Terri Flores e pelo antropologista Steve Cale viajam ao longo de um rio a fim de encontrarem uma misteriosa tribo de índios para fazerem um documentário sobre eles. Ao salvarem um homem de morrer afogado, ele oferece-se para procurar com eles a tribo de índios. Na realidade, ele é Paul Sarone, um caçador de serpentes que anda à procura da lendária serpente anaconda. Quando Cale é picado por um mosquito, Sarone, toma o comando do barco e faz deles reféns levando-os numa louca e terrível viagem a fim de capturarem a anaconda gigante...
Murdoch, um poderoso magnata com pouco tempo de vida, programa uma experiência com néctar de orquídeas sanguíneas com propriedades regeneradoras e testa-o numa cria de Anaconda. Como resultado, a cria desenvolve-se muito rapidamente e transforma-se num monstro aterrorizante, com um apetite voraz e grande poder de regeneração. Entretanto, a herpetóloga Amanda, que ajudara a criar os répteis ameaçadores e agora procura destruí-los, está à frente de uma equipa de cientistas que enfrenta as forças de segurança de Murdoch com o objectivo de apreender as referidas orquídeas e impedir que o pior aconteça.
After his fiancé sudden death, Qin Yu is convinced Cass Corporation is somehow involved and is determined to find the truth. Booking passage on the same cruise ship as former Cass employee, Jason, Qin Yu follows him. Qin Yu hopes to secure the information he needs on Cass to be able to testify against them in court. But Qin Yu isn’t the only person on board hoping to gain intel on Cass. Desperate for a story, reporter Feng Li tails both Qin Yu and Jason, booking passage on the same cruise. Unfortunately, no one has much of a chance to gain information as the ship is suddenly attacked by giant mutant snakes. Escaping the attack, the survivors find themselves on the very island Cass Corporation has been conducting their illegal experiments. Hunted by monsters of all sorts, will any of the survivors find a way to bring Cass down and make it off the island alive?
Num centro de investigação secreto numa zona rural da Europa, duas cobras de impressionantes dimensões são submetidas a diversos testes liderados por um brilhante cientista. Mas quando o investidor leva a experiência longe demais, as cobras acabam por escapar, esfomeadas e em direcção à civilização. O que se desconhece é que uma delas está à espera de crias. Começa então uma corrida contra o tempo para deter os répteis antes que eles cheguem à cidade.
Nessa sequência de Sharktopus, duas criatura híbrida atacam uma equipe de filmagem no local perto de seu ninho, quando um de seus ovos é roubado.
A set of vipers has been taken by scientists to mutate them to make a cure for cancer. As their experiment goes awry, the vipers escape into the woods - they're not only biting people, they're actually killing people, in a little town.
A gigantic serpent is captured on a remote island and shipped to an American college for experimentation.
During the construction of luxury apartment buildings a huge nest of thousands of snakes is discovered. Francis Chang (the boss) refuses to delay the construction and orders to kill all the animals. He is repeated warned by his wife, who had some nightmares concerning him and the snakes. They do not manage to kill all snakes and so they take revenge on the construction workers and Francis Chang. Soon thousands of killer snakes under the lead of a giant Boa invades the building an kill all the new inhabitants. Even a snake master can't stop them.
In an old house, a man is bitten to death by a snake. The special services and the media congregate but are only able to find a few snakes. Later, a group of cobras invade the building which threatens the lives of the habitants.
An American submarine leaves Tierra Del Fuego, and one of its crew has secretly brought aboard a container full of poisonous snakes which escape storage and bite key personnel on the submarine, causing an accident that cripples the vehicle so that it drops to the bottom of the Southern Ocean. Worse still, the snakes are still at large on the submarine and complicate the efforts of the crew to escape the sunken vessel.
A woman transforms into a snake-headed killer.
The King of the Snake Monsters is attempting to revert back to human form but is opposed by the womanizing owner of a popular restaurant that specializes in medicinal snake soup.
Police investigate a strange series of snakebite deaths.
A married man falls in love with a beautiful tour guide but is unaware of her symbiotic relationship with a deadly cobra that has killed all of her previous suitors. This was remade at least two other times.