U novom nastavku, Skretova vječita potraga za odbjeglim žirom katapultirat će ga u svemir, gdje će on igrom slučaja izazvati niz kozmičkih događaja, koji će transformirati i ugroziti cijeli svijet. Kako bi se spasili od katastrofe koja im prijeti, Mani, Sid , Diego i ostatak ekipe, morat će napustiti svoj dom i krenuti u novu avanturu, koja će ih odvesti na putovanje u nove, egzotične zemlje, gdje će upoznati mnoštvo novih likova.
Louis, a terminally ill writer, returns home after a long absence to tell his family that he is dying.
Jack Cooper could be a world-class baseball pitcher if he didn't keep buckling under the pressure. He tries to keep his spirits up after he's traded to a minor league team but loses all hope when he discovers that Ed, one of his teammates, is a chimp. Ed used to be the team mascot, but was promoted to third base when the owners realized he had a talent for baseball. As Jack struggles to get used to his new surroundings, Ed helps him regain his confidence on and off the field.
A college student, Cameron Warwick, is found dead after a college party. Jacob is set to figure out what happened to Cameron, along with discovering why he feels so ill himself.