Filmen er en fortælling om Bella Baxter, en ung kvinde, der genoplives af den geniale og uortodokse videnskabsmand dr. Godwin Baxter. Den videbegærlige Bella hungrer efter at opleve verden, så hun stikker af med Duncan Wedderburn, en slikket og amoralsk advokat, på et hæsblæsende eventyr over flere kontinenter. Befriet for datidens moraliserende bånd bliver Bellas liv en stræben efter lighed og frigørelse.
Han er et geni, hvis betagende musik fylder den populære opera i Paris i 1870 - og en ensom sjæl, som skjuler sit vansirede ansigt bag en maske og gemmer sig i katakomberne under jorden.
Han er ung, rig, ser godt ud og kan stort set få, hvad han peger på. Alligevel synes der at mangle noget i hans tilsyneladende perfekte liv. En aften møder han drømmekvinden og hans lykke er gjort, men noget er ikke som det skal være.
I denne hede, fascinerende og komplekse, psykologiske thriller er linien mellem virkelighed og fantasi håbløst sløret. César prøver at finde mening med sit liv efter en bilulykke, der efterlader hans ansigt grotesk vansiret. Han bliver derefter placeret på en psykiatrisk afdeling, anklaget for et mord, han ikke kan huske at have begået. Hans eneste håb er nu at synke dybt ned i sin underbevidsthed, og i sine drømme finde svaret, der kan gøre en ende på hans levende mareridt.
Tyskland, efteråret 1945. Den jødiske natklubsangerinde Nelly Lenz har overlevet kz-lejren, omend hendes ansigt er skamferet af skudsår. Efter omfattende plastiske operationer rejser Nelly hjem til Berlin, hvor hun møder sin ægtemand, Johnny. Han genkender hende ikke umiddelbart, og Nelly vælger at skjule sin sande identitet for at opklare, om det var Johnny, der angav hende til nazisterne.
En museumsbrand forvandler en flot mand til et menneskeligt monster, der stjæler ligene fra sine ofre fra lighuset for at skabe livagtige voksfigurer.
Den slatne gulvvasker Melvin bliver tvunget ud af et vindue og falder ned i en tønde med kemikalier. Disse forvandler ham på mirakuløs vis til The Toxic Avenger, Tromavilles beskytter! Nu har skurkene noget at bekymre sig for.
En mand bliver tvunget til at konfrontere sin fortid, da han og hans kæreste ender viklet ind i et net af løgne.
A deformed tormented girl drowns herself after her lover is framed for murder and guillotined. Baron Frankenstein, experimenting with the transfer of souls, places the boy's soul into her body, bringing Christina back to life. Driven by revenge, she carries out a violent retribution on those responsible for both deaths.
After a detective rescues a mute disfigured woman from being murdered, he takes her into his home to prevent her from staying in a mental hospital, a move which alienates his family and soon turns to obsession.
A search for a winning lottery ticket in his dead father's grave causes Sardonicus' face to freeze in a horrible grimace, until he forces a doctor to treat his affliction--with even more grotesque results! The audience gets an opportunity to vote--via the "Punishment Poll"--for the penalty Sardonicus must pay for his deeds...
A female blackmailer with a disfiguring facial scar meets a plastic surgeon who offers her the possibility of looking like a normal woman.
In a bid to distract herself from an affair, a narcissistic woman befriends a cleaning lady with burn scars, but she soon discovers that the scars may be more than skin deep.
A young girl goes to work as a live-in caretaker for a spooky old woman. She doesn't know that every night, the woman drains some blood from her to feed her strange plant.
A London opera house is haunted by tragic events on its opening night, but when its star is kidnapped, a producer tracks down the Phantom who is intent on seeking his revenge.
Glenn Manning, "The Amazing Colossal Man," believed dead after falling from the Hoover Dam, reemerges in rural Mexico, brain damaged, disfigured, and very angry.
Three sisters grow up on a chicken farm in a small town in Gifu. The oldest sister, Yukie Sawada, is engaged to be married, the middle sister, Sachiko works at a beauty salon and the youngest, Mayu, is on the track team in high school. Their happy, carefree lives are changed forever when Yukie's ex-boyfriend Suzuki commits an atrocious crime. Half-crazed and bent on revenge against the Sawada family, Suzuki mistakes Mayu for Yukie and pours acid all over her face. Overwhelmed by physical and psychological trauma, Mayu sinks deeper into depression and isolation, unresponsive to her sisters encouragement. Meanwhile, chilling news of a serial murderer, who preys on the alumni of Mayu's high school, sends shockwaves through their small town...
By day, Mari and her friends broadcast their spiritual devotion through pastel pinks and catchy evangelical songs about purity and perfection, and by night they form a vigilante girl gang, prowling the streets in search of sinners who have deviated from the rightful path. After an attack goes wrong, leaving Mari scarred and unemployed, her views of community, religion, and her peers begin to shift.
A young biologist, Mary Jane, who focuses on lepidoptery (the study of moths and butterflies), doesn't have the perfect life; she does however have what she considers the perfect son. Tragedy strikes and Mary Jane's world is disturbingly turned upside down. Fleeing the troubled "real world" she embarks upon a solitary bush project. In the isolated and surreal landscape Mary Jane starts experiencing strange phenomena. The opportunity to be a mother again presents itself, only it comes at a cost for Mary Jane and what's left of her family.
A cynical woman with a disfigured face—a hardened criminal—gets an opportunity to change her ways when she meets a sympathetic plastic surgeon. She leaves her old life behind, but soon her old friends catch up with her.