Den geniale forsker Seth Brundle (Jeff Goldblum) har fundet en metode til at teleportere levende væsener fra den ene ende af kloden til den anden. Han har bygget en maskine, der kan splitte et menneske op i atomer og samle det igen et andet sted. I hvert fald i teorien, for indtil videre er den kun testet på aber med varierende resultat. Da det endelig lykkes ham at få maskinen til at virke rigtigt, beslutter han sig for at afprøve den på sig selv. Desværre sniger der sig en lille flue med ind i teleporteren, så da Seth aktiverer maskinen, bliver han og fluen blandet sammen. Til at starte med bemærker Seth ikke, at der er noget galt, men gradvist begynder fluens DNA at overtage hans krop.
Late at night, a woman is kidnapped by an unknown assailant and taken back to his blood-spattered dungeon, where he turns her into a "flower of blood and flesh" through a series of dismemberment and evisceration.
Livet i den lille søvnige by Wheelsy, South Carolina, går sin vante gang. Den lokale sherif, Bill Pardy, har ikke meget at se til. Det værste, der kan ske på en almindelig dag, er en opsang fra byens emsige borgmester, Jack MacReady, eller at han støder ind i sin barndomskæreste, Starla, der har valgt at gifte sig med en rig, gammel gris, Grant. Men så lander en mystisk meteor i skoven uden for byen, og pludselig er Wheelsy ikke så stille mere. En fremmed organisme fra rummet kravler ud af meteoren og invaderer en af byens borgere. Den formerer sig med lynets hast, og snart er det meste af byen forvandlet til levende døde zombier. Sherif Bill får sin sag for! Han må få kontrol over byen igen, redde sin barndomskæreste og slå de snegle agtige rumvæsner ihjel.
Infected with Tomie's blood, a surgeon disappears, leaving his daughter, Yumi, to try to discover Tomie's identity and to solve the mystery of her father's disappearance.
All hell breaks loose when a giant grizzly, reacting to the slaughter of her cubs by poachers, attacks a massive rock concert in the National Park. [This sequel to "Grizzly" (1976) was left unfinished after production wrapped prematurely in 1983, and was not officially released until 2020, though a bootleg workprint version had been in circulation for some years prior to this.]
A young rookie cop and his team discover dismembered female bodies in L.A. similar to the Black Dahlia cold case from 1947. A serial killer seems to be copying the brutal massacre of 1940s Hollywood starlet Betty Short. Ultimately his investigation leads him to a frightening lair of death and torture, all part of a terrifying fantasy that the killer is trying to bring to life.
A group of "Ghost Hunters" coming back from an old ghost town and a bachelorette party returning home from Las Vegas stumble across the "Clown Motel" located in the middle of nowhere. Though no one is there to greet them, the two groups decide to stay for the evening. After a wild night of partying, they awake to find their vehicles sabotaged, leaving them stranded, left to discover if this motel is truly abandoned, or if it is home to souls of the clowns who once lived there.