凯乐布在月球采矿殖民地长大，在父亲去世后，他即将按规定永久移居一个美丽但十分遥远的星球。在离开之前，为了完成父亲的遗愿，他和三个好友迪伦、伯尼和马库斯，以及刚从地球来的艾迪森劫持了一辆巡航车前往一处神秘陨石坑，进行了最后一场冒险。

地球上接连出现神秘怪象，科学家发现某种失控的反物质反应正在威胁整个太阳系，人类生存极度堪忧……地球生死攸关之际，天才航天工程师罗伊（布拉德·皮特 饰）被派往外太空，试图揭开谜团拯救人类。这是一场横跨地球、月球、火星、海王星，穿越整个太阳系的硬核冒险，一路危机重重险象环生，罗伊直面爆炸、陨石、月球飙车枪战、神秘生物等意想不到的考验，还找回了失联 20 年的父亲！当年罗伊的父亲（汤米·李·琼斯 饰）离开地球探寻外星智慧生物，结果任务失败，消失在茫茫宇宙之中。如今父子重逢，罗伊在太空深处发现了不为人知的秘密，渐渐触达所有事件的终极真相……

The year is 2087, the setting is the moon. Pluto Nash, the high-flying successful owner of the hottest nightclub in the universe, finds himself in trouble when he refuses to sell his club to lunar gangster Mogan, who just happens to be helping the mysterious Rex Crater mastermind a plan to take over the entire moon.

In England, a group of space scientists led by Bernard Quatermass, who have developed plans for the first Moon colony, learn that a secret, ostensibly government-run, complex of identical design has been built in a remote part of England and is the focus of periodic falls of small, hollow "meteorites" originating in outer space. Quatermass determines to investigate and uncovers a terrifying extraterrestrial life form which has already begun action to take over the Earth.

The residents of a town displaced by an industrial accident agree to take over a failing mining base on the Moon as their new place to live and work. Their first big test comes in the form of a wave of radiation from a massive solar flare.

After returning from a year-long Moon mission, Cassie, a NASA botanist, finds herself in a remote cabin in the woods, where her estranged twin sister, Stella, a former NASA architect, has found a new life with climate activist Bryan. Old wounds resurface as the sisters attempt to pick up the pieces of the rivalry that broke them apart.

The year is 2049. 200 years after the great Californian goldrush. The new generation of gold diggers are just as full of gold fever as their ancestors.