داستان روایتی نوین از شخصیت شرلوک هولمز است. او پس از اعتیادش به مواد مخدر برای ترک به نیویورک می‌آید و سعی می‌کند با کمک دکتر جون واتسون آن را ترک کند و همزمان نیز پرونده‌های جنایی را حل کند.

از دیگر ویژگی سریال زن بودن دو شخصیت اصلی آن یعنی دکتر واتسون و موریارتی است.

Nick Fallin is a hotshot lawyer working at his father's ultrasuccessful Pittsburgh law firm. Unfortunately, the high life has gotten the best of Nick. Arrested for drug use, he's sentenced to do 1,500 hours of community service, somehow to be squeezed into his 24/7 cutthroat world of mergers, acquisitions and board meetings. Reluctantly, he's now The Guardian - a part-time child advocate at Legal Aid Services, where one case after another is an eye-opening instance of kids caught up in difficult circumstances.

Johnny Miller was a typical 15-year-old until his father committed suicide. Now Johnny lives in Palm Springs with his mother and her new husband. On the outside, Palm Springs is a paradise - but as Johnny learns the secrets that lie just beneath the surface of this seemingly typical neighborhood, he and his family wonder how well they really know the people who live right next door.

After hitting rock-bottom from his own addictions during the birth of his twins, William Banks strikes a tentative deal with God. In exchange for a second chance, he vows to kick his addictions and dedicate his life to helping others. Now, along with his unconventional team, he helps people get clean from their own addictions of sex, drugs, alcohol and gambling by any means necessary.