Richard Kimble is falsely convicted of his wife's murder and given the death penalty. En route to death row, Kimble's train derails and crashes, allowing him to escape and begin a cross-country search for the real killer, a "one-armed man". At the same time, Dr. Kimble is hounded by the authorities, most notably dogged by Police Lieutenant Philip Gerard.

Jeanne Deber, known as "La Mante", the famous serial murderer who terrorized France more than 20 years ago, is forced by the police to come out of isolation to track down her copycat. She agrees to collaborate on one condition: to have only one interlocutor, Damien Carrot, her son, who became a cop because of the crimes of his mother, and who refuses all contact with her since her arrest.

Duo's van bekende Vlamingen slaan gekleed in oranje overalls op de vlucht en proberen uit de klauwen van de jagers te blijven. Welk duo ontpopt zich tot slinkse boeven?