After moving into the quiet town of Hinamizawa, Maebara Keiichi spends his days blissfully in school often playing games with his local friends. However, appearances can be deceiving. One fateful day, Keiichi stumbles upon news of a murder that had occurred in Hinamizawa. From this point on, horrific events unfold in front of Keiichi, as he soon learns his close friends may not be all that they seem. Based on the amateur mystery game by 07th Expansion, the story is told in a series of different scenarios.

Six months after deciding to pull herself together and get sober, Bridget witnesses a murder. Realizing her life is in danger and not trusting the FBI to protect her, she runs to her wealthy twin sister, Siobhan, in New York. Things start out well—with the two patching up a fractured relationship—when Siobhan suddenly goes missing. Bridget assumes her sister's identity, but soon learns that Siobhan's life is not as perfect as it looks and she is no safer than she was before

One day at work, Jodie momentarily glances out of the window and in a split second her life descends into freefall. What she notices seems innocuous – two men walking on the opposite side of the road – but she’s actually witnessed a killer and his victim moments before a murder.

Nearly a quarter of a century after she witnessed the murder of her mother, Jane Fielding is married and has a daughter of her own, but the traumatic events of that day still haunt her. She constantly aware that the murderer is still at large. While on a routine visit to hospital, she locks eyes with the man believes killed her mother.