Slowed by age and failing eyesight, crack baseball scout Gus Lobel takes his grown daughter along as he checks out the final prospect of his career. Along the way, the two renew their bond, and she catches the eye of a young player-turned-scout.

Veteran catcher Crash Davis is brought to the minor league Durham Bulls to help their up and coming pitching prospect, "Nuke" Laloosh. Their relationship gets off to a rocky start and is further complicated when baseball groupie Annie Savoy sets her sights on the two men.

When his star recruit botches a Major League Baseball debut, humiliated talent scout Al Percolo gets banished to rural Mexico, where he finds a potential gold mine in the arm of young phenom Steve Nebraska. Soon, the New York Yankees put a $55 million contract on the table—provided a psychiatrist can affirm Nebraska's mental stability.

Dock Ellis pitched a no-hitter on LSD, then worked for decades counseling drug abusers. Dock's soulful style defined 1970s baseball as he kept hitters honest and embarrassed the establishment. An ensemble cast of teammates, friends, and family investigate his life on the field, in the media, and out of the spotlight.

On April 20, 1990, Seattle Mariners' starting pitcher, Brian Holman, faces off against the Oakland Athletics in an infamous performance that stands as one of the most rare events in Major League Baseball history.