Cougar Town mostra a história é sobre Jules Cobb (Courtney Cox), uma quarentona que vive com o filho em uma pequena cidade da Flórida, onde a única coisa interessante é a equipe de futebol americano da escola local: os Cougars. Jules insiste em não cair no clichê de se deixar seduzir pelos jovens esportistas, mas em uma louca noite de bebedeira entrega-se apaixonadamente a um rapaz muito mais jovem do que ela. A partir desse momento, Jules se transformará na mãe-modelo para os amigos de seu filho e terá que lidar com todas as dúvidas, conflitos e divertidas situações que surgirão.
Budding Portland restaurateur Nate's world is turned upside-down when he returns home from a business trip to find his lothario best friend and roommate, Jimmy, dating his recently separated mother, Lydia. To make matters worse, Nate's previously disinterested dad, Harrison is now determined to win Lydia back.
Michiko is 30 years old. She keeps looking for a job after her previous employer went bankrupt, but she is unable to find work. Michiko still supports her younger boyfriend and her savings are almost gone. Then, Michiko meets her ex-boss, Ayumu. She was scared of Ayumu when they worked together. Ayumu now runs a tea room which his grandmother ran. Michiko decides to work part-time at Ayumu's tea room. There, she encounters various troubles everyday. Ayumu helps Michiko, which allows her to see a different side of him that she never noticed before.