Set in a tenement, a lonely confirmed bachelor occupies a room across the hall from a dour spinster. Children run amok in the hallways playing pranks on the two. A little girl from the floor above, now alone in the world, brings the pair together and brightens their lives.
A teenage orphan (who believes herself to be "hoodooed") is taken in by a childless couple and quickly falls for the boy next door; Her luck seems to have changed. But the idyll is broken up after a trip to the movies-- It seems the 'hoodoo' has returned after she tries to replicate what she'd seen on the screen.
Wealthy Jack Stimson (Jay Belasco) falls in love with Broadway diva Velma Vrooman (Gretchen Lederer), and for her sake bankrolls the musical production in which she is currently starred. But when Velma proves to be fickle and unreliable, Jack shifts his affections to humble chorus girl Bobbie (Louise Lovely).
Stella Maris is a beautiful, crippled girl, who is cared for by a rich family. They shield her from the harsh realities of the world, so that she has no idea of the cruel things that some people do. Unity Blake is a poor orphan all too familiar with the harsh realities of the real world. These two young women both fall in love with John, love which is complicated by the fact that he is still married to (though separated from) a bad wife.
The first part is pathetic and shows Eleanor Hamlin (Edith Roberts) severing home ties with her grandparents to be "adopted" by a party of idle rich on the cooperative plan. The parties adopting her are single, and one of them, Beulah Page (Winifred Greenwood), has her own ideas on the subject of raising the young - these ideas absolutely precluding the main requisite, love.
Mickey, an orphan who has been brought up in a mining settlement, is sent to New York to live with her aunt.
Annie, left orphaned after the death of her mother, goes to live in an orphanage where she tells her fellow orphans stories of ghosts and goblins. The matron of the orphanage finds Annie's closest relative, the abusive Uncle Thomp. Her uncle who puts her to hard work doing hard labor on his farm, belittling her all the while. Big Dave, a neighbor and tough cow-poke sees this and comes to her aid. Dave becomes her protector. Eventually Annie goes to live with Squire Goode and his large family. There, she entertains the children of the household with her stories, but sees her abusive aunt and uncle as her chief tormentors. She tells stories of how the goblins will take away the children if they are not good. Each story she tells is illustrated. War breaks out and Dave, who Annie adores, enlists. Uncle Thomp, hearing that Dave has been killed in action, takes pleasure in telling Annie the news. Broken-hearted, Annie falls ill and dies in bed, surrounded by family.
Wealthy Jarvis Pendleton acts as benefactor for orphan Judy Abbott, anonymously sponsoring her in her boarding school. But as she grows up, he finds himself falling in love with her, and she with him, though she does not know that the man she has fallen for is her benefactor.
When Pollyanna is orphaned, she's sent to live with her crotchety Aunt Polly. Pollyanna discovers that many of the people in her aunt's New England hometown are as ill-tempered as her aunt. But Pollyanna's incurable optimism - exemplified by her "glad game", in which she looks for the bright side of every situation - brings a change to the staid old community.
Aurora Meredith is the daughter of the village blacksmith. Because she has a promising voice, her family does everything they can to develop her talent. A wealthy New York woman hears her sing and sends her to Europe to study. But the woman dies, and Aurora borrows money for her last year from a hot-blooded Italian man. Instead of being paid back financially, the Italian wants her love, and she rejects him.
An orphan named Innocence leaves her county home after her foster-father dies. She travels to the city and makes a living as a novelist. Subsequently, she has an affair with a painter named Amadis de Jocelyn, who later dumps her.
A French orphan girl is adopted into the home of wealthy Americans. There she becomes romantically involved with a farm worker and at the same time entangled in the deteriorating marriage of the American couple who rescued her.
Anna Moore, a poor orphaned country girl, and her little brother, Tommy, live with hypocritical Squire Simpson, who conspires with his son to acquire the inheritance due the girl.
Tokutaro is an orphan child who becomes a street candy vendor. He sells candies, humming a song he learned long ago from his mother. One day he met with thieves along the way and this encounter changes their lives in ways they cannot imagine.
A feisty homeless orphan girl struggles with winter cold and hunger.
Orphaned as children, David and his sister are sent to live with separate families, where both are abused, and his sister dies. Filled with hostility, David now an adult, goes on a mission to seek vengeance on the adopting family.
An orphan boy wins a prize for his drawing.
During a tempestuous storm, a lighthouse keeper finds an infant girl who washes ashore tied to some wreckage. He adopts her and they become inseparable. Eventually her real family finds her and wants her to live with them.