在太空旅程沉思無垠宇宙、人類進化與科技發展的關係，主題視野恢宏，敘事形式開放，超越類型框框而漫遊於哲學與想像天地，古今上下而求索。藉着電腦密謀叛變，指出人類終有一日會淪為科技奴隸，實在極有遠見。
月能公司在月球背面設有開採基地，山姆·貝爾（Sam Bell，山姆·洛克威爾飾）則是這個基地上唯一的工作人員，他在妻子剛懷孕時與公司簽了三年的合約後並前往月球，基地內只有一個機器人戈蒂（GERTY，凱文·史貝西配音）陪著他，這三年間，他將開採出來的氦-3裝進小太空船並讓其自動飛回地球，而月球的通訊衛星因太陽風故障，所以地球無法與月球進行即時連繫，只能事先錄好影片並藉由木星的衛星傳至月球，山姆藉此看著妻子傳來的影片，並錄製自己的影片寄回地球。過了兩年多，合約只剩兩周，山姆再過不久就能離開月球並帶著大筆獎金回到地球，他卻在探勘時意外撞上採礦車而昏迷。山姆醒來後發現自己躺在基地醫護室，離開醫護室後意外發現戈蒂正與公司高層進行即時對話，因而認為高層其實另有隱情，復健結束後他打算去事故發生地查看，但是公司不允許，並聲明已派出支援部隊前往月球，於是山姆拿工具破壞管線，並告訴戈蒂有隕石撞到基地，需要到外面維修，在戈蒂答應保密後山姆藉機前往事故發生地點，意外發現了另一個昏迷的自己。
The Lunar Base Ark explores ore and unexpectedly is hit by a meteor shower and has severe damages. Colonel Gerard Brauchman sends the crewwoman Ava Cameron to repair a wing that is full of CO2. Dr. Lance Krauss warns that the gas may cause paranoia and hallucinations. Ava brings a sample of the meteor for analysis and Dr. Krauss finds that there are spores attached to the meteor. Ava accidentally cuts her finger in a sample but she hides the cut from the doctor. Soon Ava gets pregnant and delivers an alien offspring. However, neither Col. Brauchman nor Dr. Kraus believes in her words and they believe that Ava is delusional. He offspring bites the crewman Bruce Johns and the crew discovers that Bruce has been cloned by the alien. Soon they find how dangerous the clone is.
At the turn of the century, all of the Earth's monsters have been rounded up and kept safely on Monsterland. Chaos erupts when a race of she-aliens known as the Kilaaks unleash the monsters across the world.
When odd reports are received through official channels stating that the President of the United States is being held captive on a secret international moon base called Vegan and that he has been replaced on Earth by a clone, the US Marshall Service immediately sends their 'best' man, Dix, on the mission.
After returning from a year-long Moon mission, Cassie, a NASA botanist, finds herself in a remote cabin in the woods, where her estranged twin sister, Stella, a former NASA architect, has found a new life with climate activist Bryan. Old wounds resurface as the sisters attempt to pick up the pieces of the rivalry that broke them apart.
The most dangerous criminals in the universe escape from the Off-World Penitentiary and stow away to the quiet Moonbase Waste Disposal Plant. Hidden beneath the lunar surface lies an arsenal of nuclear warheads- the inmates' passport home to earth. Moonbase Commander John Russell launches a desperate fight to save his crew from a force capable of laying waste to an entire planet.
After an atomic explosion blasts the Moon out of Earth orbit, Moonbase Alpha drifts in space, with 300 people on board. When a rescue team from Earth arrives in a faster-than-light space ship, everyone is overjoyed that they can now return to Earth. But Moonbase Commander John Koenig, having undergone an experimental brain soothing process after receiving a concussion in a crash on the Lunar surface, sees not friends from Earth but gruesome monsters which have telepathically caused all others on Alpha to see an illusion of an Earth party. The aliens are desperate for radiation and plan to manipulate the Alphans into detonating nuclear waste on the Lunar surface, reducing the Moon and everyone on it to dust. Koenig must expose this conspiracy to save his people. Compiled from the two part episode The Bringers Of Wonder from the TV series Space: 1999's second series.
The spaceship AAB-Gamma is dispatched from FAFC headquarters in Japan to make a landing on the planet Mars and investigate reports of UFOs in the area. As they near the red planet, they encounter a mysterious UFO that coats the ship's hull with unusual spores. Taking one of the specimens back to earth, it soon develops and grows into a giant chicken-lizard-alien monster that tramples Japan.
A group of scientists are possessed by an alien force when they investigate a meteor shower in a rural field.
In this science-fiction action opus, intergalactic extremist Alex Windham has seized control of Dome 4, a scientific outpost on another planet, after escaping from a penal colony on Mars. Windham is forcing the staff of Dome 4 to construct new weapons that he can use to destroy his enemies, but what he doesn't know is that one of his captives is the wife of interstellar lawman Chase Moran, and Mor
Meet the teams of brilliant engineers and bold explorers behind NASA’s latest moon mission.
It’s the year 2075. Jung-won, a pathologist, has a recurring nightmare about her sister’s death. In order to cease the nightmares, she visits the sea of tranquility, called Moon. There she undergoes a strange experience that causes the death of her sister.
A mysterious plant found on the surface of the moon wreaks havoc on the Jackson Lunar Base when its spores change the base's crew into leafy, undead creatures.