Michelle Rodriguez spiller den hårdkogte lejemorder Frank Kitchen. En dag slår Frank den forkerte person ihjel, og da han vågner op, opdager han, at han er blevet forvandlet til en hun. En kirurg blot kendt som 'The Doctor' (Sigourney Weaver) har foretaget en kønsskifteoperation på Frank og forvandlet ham til en smuk kvinde. Den ubehagelige overraskelse kræver naturligvis en grusom hævn!

Tolv år tilbage mistede plastikkirurgen Robert Ledgard sin kone, som omkom af forbrændinger efter en bilulykke. Lige siden har Ledgard været besat af at udvikle en revolutionerende hudbehandling til brandsår. Til det formål holder han en levende forsøgskanin, den unge Vera, fanget i kælderen af sin overdådige luksusvilla.

Den lokale helt i en bydel i N.Y. sætter sig en nat for at stoppe nogle uroligheder i sit lejlighedskompleks. På vej op ad en trappe falder han imidlertid om med et hjerteanfald, der efterlader ham delvis lam i højre side af kroppen. Hans læge anbefaler syngetimer for at træne stemmen op igen, og han føler sig tvunget til at opsøge sin overbo - en larmende drag queen. De to kan selvfølgelig ikke fordrage hinanden, da ex-strisseren er brændende homofob, så det bliver et anstrengt forhold, indtil de så småt opdager de gode sider hos hinanden.

Elvira Weishaupt, once a burly working-class butcher, has made an enormous sacrifice for love. She has undergone a sex change for a romantic interest who has abandoned her, and she now must struggle to reconcile her past life with her present identity.

The film tells the story of Matt, a male hockey player who dies in a game and comes back to life as Sara Bryan, a female figure skater due to an accident made by an angel that caused the hockey player to die. Both share the dream of competing in the Winter Olympics. The male hockey player specified that if he returned to earth, he wanted to have a chance to win an Olympic Gold medal on ice leaving the detail that he wanted to be on the hockey team implied. With time running short Matt has to get skating lessons from Sara's one-time rival if he wishes to earn gold.

In foggy London Dr Jekyll experiments on newly deceased women determined to discover an elixir for immortal life. Success enables his spectacular transformation into the beautiful but psychotic Sister Hyde who stalks the dark alleys of Whitechapel for young, innocent, female victims, ensuring continuation of the bloodstained research. With each transformation Sister Hyde becomes the more dominant personality, determined to eventually suppress the frail, ineffectual Dr Jekyll forever.

Historien om thai kick bokseren Nong Toom Prinya Charoenphols liv, og fortæller den intense historie om hans opvækst i et lille samfund, i en familie, hvor hverdagen var præget af fattigdom. Han bliver drillet pga. sit delikate ydre, og han føler sig på et tidligt tidspunkt mere som kvinde end som mand. Da han en dag bliver tvunget til at forsvare en af sine venner, opdager han, at han har talent for kick boksning. Vi følger Nong Toom gennem hans ungdom i et kloster, hvor han energisk følger et stramt træningsprogram, og endelig i ringen, hvor hans mål er at vinde så mange kampe som muligt og dermed så mange penge som muligt, så han kan få en kønsskifte operation.

A seventeen-year-old boy follows the painful path to discovering that he is transsexual.

Hank marries the divorced Joan, who's the mother of teens Sebastian and Jessica. After living with his new family for years, Hank announces that he's getting a sex change operation. The family deserts Hank, with Jessica going her own way and Sebastian staying with his mom. But Joan becomes an alcoholic, so Sebastian moves back in with Hank — now Henrietta — who turns out to be far more supportive than anyone else.

When a young hippie couple enters an upper-class mansion, a carousel of sex and misunderstandings awaits.

Teenager Anna falls in love with and gives her womanhood to the middle-aged womanizer Eric who promises her marriage. Upon her brother's insistence to meet the man, she realizes then that Eric is married and eventually commits suicide. Outraged, Martin (brother), who is a sex-change surgeon, abducted and performed an operation on Eric. Shameful of his inadequacy, Eric evades his wife's sexual needs and sexual attractions to other women.

Jana says goodbye to her band members, friends, ex-girlfriend and her family. They all share a feeling of regret saying goodbye to her, but also joy for her bright future in Michigan, where she's going on post graduate studies. Only her sister knows a secret, that Jana is not going away to study, Jana is going away to have her sex change. These are her two days to say goodbye to her life.

Pioneering trans writer Max Wolf Valerio talks about his life and experience of transition in this groundbreaking documentary short, one of the very first portraits of a trans man on film, directed and produced by noted filmmaker Monika Treut.

The unbelievable story of 22 year old Or, who secretly finances his sex change operation in Thailand by lying to his conservative parents and then returns home as a woman to face her new life, her family and the cost of living her dream

Pidgeon Pagonis, a lead activist and educator from the intersex community, crusades for body autonomy and the freedom to choose one’s own path.

Captain Ian Hamilton is one of the most highly decorated officers in the British Army - and the first officer and paratrooper to undergo a sex-change operation to become Capt. Jan Hamilton

Sora and Umi (both played by Lee Tae-kyung) who were born to a Japanese father and a Korean mother and raised in South Korea. Sora now lives in Shanghai and works as an illustrator. When she meets a Japanese guy named Mochizuki, they become close. This is when her sibling Umi visits. Umi was born inter-sex and had undergone gender reassignment surgery to become a woman. Umi encourages Sora and Mochizuki to fall in love, but Sora becomes mentally unstable.

Rich Bradford seems like your everyday great boyfriend. He has a good job, a nice car and the perfect girlfriend, Amanda. What she doesn't know about him is that he is only after one thing. His best friend Stu from college days knows how much of a womanizer Rich really is. When the day comes that Rich thinks he is finally going to romance Amanda, he is interrupted by her gay friend David who walks in on them. The same day he is dumped by Amanda is Rich and Stu's fraternity reunion. How can Rich go alone? All of his fraternity brothers always saw him with a girl. Stu on the other hand gets a visit from an old fraternity brother he has kept in contact with over the years. Much to Stu's surprise, when the brother comes, he is now a beautiful woman, Erica. Stu brings Erica to the reunion and she catches Rich's eye. Will Rich finally get his just desserts or will he realize in time that his dream girl used to be a man?