Alice Racine får vite om en dødelig terrortrussel i London og vender tilbake til jobben i CIA, men oppdager at byrået kan være kompromittert.

A deadly virus has spread across the globe. Contagion is everywhere, no one is safe, and no one can be trusted. Four friends race through the back roads of the American West on their way to a secluded utopian beach in the Gulf of Mexico where they could peacefully wait out the pandemic. Their plans take a grim turn when their car breaks down on an isolated road starting a chain of events that will seal their fates.

An alien microbe lands in remote Siberia in the 1950's. In the year 2004, US scientist working at a top secret underground lab in Alaska clone the microbe. A garbled distress signal is heard from the lab just before a complete lock down of the facility. This is the last word sent out from the scientists. A team of scientists and military personnel are in charge of finding out what went wrong.

In this non-canonical entry in the Resident Evil/Biohazard franchise, five members of the U.B.C.S. are sent to Racoon City to trace Dr. Cameron and, foremost, her research. However, the horrors they encounter are beyond their imagination.

Alice er tilbake i den fjerde utgaven av Resident Evil-sagaen. Nå, uten super menneskelige krefter, vil hun slå seg sammen med de andre overlevende, Claire og Chris, slik at de sammen kan ta opp kampen mot hæren av levende døde og knuse Umbrella Corporation hvis virus har skapt dem.