改編自DC Elseworlds獨立系列暢銷漫畫，將克蘇魯元素帶入蝙蝠俠故事！感受不同以往的全新宇宙，黑暗騎士這次要面對的並非罪犯而是超自然事件！布魯斯韋恩的父母被邪教教徒所殺害，使他踏上長達20年的流浪之旅。如今布魯斯韋恩終於歸來，但地獄接踵而至：來自另一個時空的惡魔正在甦醒。決定以蝙蝠俠身分承擔責任的布魯斯韋恩，在面對未知事物時是否還能保持理智...？

延續第一集的情節，法蘭克的姪女克絲蒂（艾雪莉羅倫斯 飾）由於第一集的驚恐遭遇而必須進入精神病院治療。本以為這裡是個安全的所在，能讓她擺脫過往的痛苦及恐怖回憶，但是克絲蒂的主治醫師查納德，卻是個醉心邪惡的人。 他期望能解開地獄之謎，釋放鬼魅大軍來到人間，當他知道克絲蒂的過去，他就喚醒克絲蒂死去的繼母茱莉亞（克萊兒希金斯 飾），並且利用另一名病患解開魔術方塊之謎。他果然成功地開啟了地獄之門，並召喚針頭鬼及鬼魅大軍來到世界，這群地獄使者也因此得以在人間大開殺戒、濫殺無辜。

法蘭克斯坦博士著迷於人類心跳的奧祕，矢志透過自己的雙手創造全新的生命，無奈他狂傲的想法並不為學界所接受。不顧親友和未婚妻的反對，他帶著助手來到一座僻遠古堡，從墓地挖掘殘屍、實驗室偷取大腦，執意繼續著違逆上帝的計畫。在一個雷狂雨驟的夜晚，他的研究終於出現曙光，科學怪人誕生了！

In the 1960s, a nurse's last day on her job is ruined when a doctor inadvertently creates a cyst monster that terrorizes the office.

An unnamed doctor has always had everything he's ever wanted, but that has only made him develop more extreme and depraved needs. He kidnaps a young couple in the prime of their life together and forces them into a game of torment that slowly extinguishes their hopes for survival.

After Malukan immigrants engage in a string of corpse mutilations at various New York City hospitals, a doctor and a morgue assistant travel to the Maluku Islands to investigate.

An insane surgeon's obsession with an actress leads him to replace her wounded pianist husband's hands with the hands of a knife murderer--hands which still have the urge to throw knives.

原本要去還債的葛蕾斯，陰錯陽差地被捲入一場搶案。因拙劣的手法，搶匪中的一名成員不幸中彈，於是他們挾持著葛蕾斯，一行人逃到一間偏遠的農場，希望可以借宿一晚。當發現新聞報導著他們被通緝的消息時，為了不被農場主人揭發，搶匪決定將其滅口，卻意外發現這間農場是由一群從事活摘器官的人所經營的，頓時，保住性命對這群罪犯來說，成了比躲警察更重要的事…

After a team of surgeons botches his beloved wife's operation, the distraught Dr. Phibes unleashes a score of Old-Testament atrocities on his enemies.

A severely injured man and woman awake in an abandoned sanitarium only to discover that a sadistic caretaker holds the keys to their freedom and the horrific answers as to their true identity.

Deep within the mysterious Arboria Institute, a disturbed and beautiful girl is held captive by a doctor in search of inner peace. Her mind controlled by a sinister technology. Silently, she waits for her next session with deranged therapist Dr. Barry Nyle. If she hopes to escape, she must journey through the darkest reaches of The Institute, but Nyle wonʼt easily part with his most gifted and dangerous creation.

University professor George Kingsley is struck by gangsters while crossing the street, leaving him with brain damage and one of the gangsters, Cannon, paralyzed. Kingsley's friend Dr. Sovac attends to both men, and when Cannon offers him a reward for aiding his recovery, Kovac transplants part of Cannon's brain into the dying Kingsley's skull, creating a dual personality.

Dr. Bill Cortner and his fiancée, Jan Compton, are driving to his lab when they get into a horrible car accident. Compton is decapitated. But Cortner is not fazed by this seemingly insurmountable hurdle. His expertise is in transplants, and he is excited to perform the first head transplant. Keeping Compton's head alive in his lab, Cortner plans the groundbreaking yet unorthodox surgery. First, however, he needs a body.

A professor and his students perform a dangerous experiment that causes a young woman to lose her sanity.

In this thriller, psychiatrist Dr. Cross kills his wife and expects to get away with murder, until he discovers that the slaying was observed by a next-door neighbor, Janet Stewart. As Janet attempts to convince her husband of the doctor's dastardly deed, Cross shows up to advise him that Janet is in dire need of some in-depth counseling.

When Chris and Andy order a model from an escort service, they find that something is unnaturally wrong with Natasha, something deadly wrong.

An ex-vaudeville actor is working as the assistant to a doctor who has Frankenstein aspirations. The ex-vaudeville actor kills the doctor and decides to assume the identity of the dead physician.

A brilliant but deranged neurosurgeon becomes obsessively fixated on a judge's daughter. With the help of an escaped criminal whose face he has surgically deformed, the mad man lures her, her father, and her fiancé to his isolated castle-like home, where he has created a torture chamber with the intent of torturing them for having 'tortured' him.

A scientist working on cures for rare afflictions, such as a bone softening agent made from molds to allow him to correct the spinal deformity of his nurse, finds the physical causes of lycanthropy in wolf-man Larry Talbot and of vampirism in Count Dracula, but himself becomes afflicted with homicidal madness while exchanging blood with Dracula.

When his experiments into a powerful new anesthetic go hideously awry, respected physician Dr. Jekyll transforms into the hideous Jack Hyde. As his wife Elisabeth passes her time in charitable work, rehabilitating the district's fallen women, Hyde is drawn into an escalating cycle of lust and murder that seems to know no bounds.