A reporter is murdered while driving to his job. The Police are contacted by a clairvoyant who saw the death in a vision, but some dark force is preventing him from seeing the man behind the crime...

The evil Dr. Mabuse develops a death ray with which he threatens the world.

The supposedly dead and buried Mabuse returns to his criminal activities, as his longtime foe Police Inspector Lohmann, a dauntless girl reporter, and an American - who may be an FBI agent, or maybe a Chicago mobster - investigate a series of gruesome murders connected to a maximum security prison and involving a minister who has written a book called "The Anatomy Of The Devil".

The spirit of the evil Dr. Mabuse takes over the body of a famous professor. The professor/Dr. Mabuse then begins a new crime wave that terrorizes the city.