Mamma Moo is a typical cow, besides that she wants to do so many uncowly things. Her idea of fun is biking and dancing, and when she meets Crow her happiness is complete - the fun is so much bigger when you have a friend. There's a catch; Crow does not want to be friends with a cow, especially not such a peculiar one.

Inspired by the book The Lives of the Most Excellent Painters, Sculptors, and Architects by painter Giorgio Vasari, this historical soap opera, in which betrayals, kidnappings, murders and police investigations are interwoven, relates the discovery by the Italians of the secret of Flemish painting around 1470.