A quiet woman receives a social media request from a middle-school friend, who she doesn’t remember fondly. The two meet at a hotel’s restaurant where they find a room numbered 666 containing Rokuroku, a long-neck woman wearing a red kimono.

Intergalactic bounty hunters Iria and Bob return to track down an ancient mystical relic. When a second Zeiram unit shows up and goes berserk, it takes all of Iria's resources to survive a deadly game of cat-and-mouse with the fearsome space creature.

In a futuristic version of medieval Japan, a band of swordsmen battles an evil warlord and his mechanical army of ninjas, and are aided by a mysterious heroic cyborg ninja, Shiranui.

Teppei and Kamiya, two average joes working in the electronic services industry, stumble upon the intergalactic bounty-hunter Ilia, and her partner, the artificial intelligence named Bob. Both men are accidentally transported to the Zone, a virtual reality in which Bob has trapped Ilia's latest prey, a biological weapon named Zeram. The Earth natives must both survive the experience and help Ilia capture Zeram before the Zone disappears around them.

A monster hunter goes after a beast that could be her brother.

A retired warrior comes to see his former lord and learns that someone is making indestructible swords from some unknown metal. He is sent together with a swordsman to investigate the source. Along the way they meet a young girl working as a beekeeper. She is later witness to the appearance of three strange females from another dimension. They are searching for a lost weapon that has landed on earth and as one of them lay dying she enlists the girl to help them control the strange beast/weapon. Meanwhile the warrior and the swordsman learn that an old nemesis has created the swords from the shell that surrounded the alien weapon. Soon the alien beast/weapon is awakened and battle for control ensues.

Behind the scenes of Zeiram 2