Cherry Falls è una tranquilla cittadina della Virginia dove ha preso a colpire un serial killer. L’assassino segue un preciso criterio: le vittime sono tutte adolescenti, frequentano la George Washington High School e sono vergini. Quando gli studenti si rendono conto del pericolo, cercano di mettersi in salvo con una grande festa in cui perdere la verginità...

Francis and Blake Falls are Siamese twins who live in a neat little room in a rundown hotel. While sharing some organs, Blake is always fit and Francis is very sickly. Into their world comes a young lady, who turns their world upside down. She gets involved with Blake, and convinces the two to attend a Halloween party, where they can pass themselves off as wearing a costume. Eventually Francis becomes really ill, and they have to be separated. They then face the physical and mental strains that come from their proposed separation.