איון פלאקס היא סוכנת חשאית שעובדת בזריזות, יעילות ובלי הרבה רעש. היא גם עושה את זה חצי עירומה ומצליחה למות כל פעם מחדש, לצלילי פסקול מטריד במיוחד.

Liquid Television is an Emmy Award–winning 1990s animation showcase that appeared on MTV. It has served as the launching point for several high-profile original cartoons, including Beavis and Butt-head and Æon Flux. The bulk of Liquid Television's material was created by independent animators and artists specially for the show, and some previously produced segments were compiled from festivals such as Spike and Mike's Sick and Twisted Festival of Animation. Mark Mothersbaugh composed the show's theme music.

There were also a large number of animation pieces adapted from the work of Art Spiegelman's comic compilation, RAW. RAW featured underground cartoonists such as Mark Beyer, Richard Sala, and Peter Bagge. In particular, Dog-Boy by Charles Burns was based on the artist's series from RAW.