Bruiser is the story of a man who has always tried to fit in. He keeps his mouth shut, follows the rules, and does what he's supposed to do. But one morning, he wakes up to find his face is gone. All the years of acquiescence have cost him the one thing he can't replace: his identity. Now he's a blank, outside as well as in, an anonymous, featureless phantom. Bent on exacting revenge, he explodes. He isn't going to follow the rules anymore.

The world is full of zombies and the survivors have barricaded themselves inside a walled city to keep out the living dead. As the wealthy hide out in skyscrapers and chaos rules the streets, the rest of the survivors must find a way to stop the evolving zombies from breaking into the city.

A terrified group of college film students record the pandemic rise of flesh-eating zombies while struggling for their own survival.