A shy but gentle man named Clifford Skridlow is a professor of comparative literature at the financially-strapped fictional Monroe College in Chicago. A chance encounter with four beautiful women at a restaurant changes his life forever.

After losing their academic posts at a prestigious university, a team of parapsychologists goes into business as proton-pack-toting "ghostbusters" who exterminate ghouls, hobgoblins and supernatural pests of all stripes. An ad campaign pays off when a knockout cellist hires the squad to purge her swanky digs of demons that appear to be living in her refrigerator.