En dag får den brittiske konstnären Colin Ware (Colin Firth) en bröllopsinbjudan. Den kommer från hans egen fästmö Vera (Minnie Driver) - som bestämt sig för att gifta sig med en annan man. Chockad och olycklig tar Colin sin tillflykt till ett litet motell i den amerikanska småstaden Hope Springs. Där tänker han försörja sig som porträttecknare och försöka glömma Vera.

After the death of her father, Little Voice or LV becomes a virtual recluse, never going out and hardly ever saying a word. She just sits in her bedroom listening to her father's collection of old records of Shirley Bassey, Marilyn Monroe and various other famous female singers. But at night time, LV sings, imitating these great singers with surprising accuracy. One night she is overheard by one of her mother's boyfriends, who happens to be a talent agent. He manages to convince her that her talent is special and arranges for her to perform at the local night club, but several problems arise.

In a typical English working-class town, the juveniles have nothing more to do than hang around in gangs. One day, Alan Darcy, a highly motivated man with the same kind of youth experience, starts trying to get the young people off the street and into doing something they can believe in: Boxing. Darcy opens a boxing club, aiming to bring the rival gangs together.

Mengele’s fugitive years in South America told from his point of view. The notorious Nazi doctor found refuge in South America at the end of WWII and was never captured. Mengele died in Brazil in 1979 without having been judged for his crimes.