When a man's best friend is killed on the streets of New York, he transforms into a violent killer, turning New York into a war zone.

In the year 2024, the ozone layer is believed to have been destroyed, and it's up to MacLeod and Ramirez to set things right. Opposition comes from both the planet Ziest (MacLeod and Ramirez's homeworld) and a corporation profiting from the supposed lack of ozone. Also, flashbacks show the story behind MacLeod and Ramirez's exile from Ziest.