Den galne professorn Gangreen ser till att en ny armé av stora mördartomater ser dagens ljus. Numera kan de också förvandla sig så att de ser ut som människor.
Ex-Green Beret Matt Collins is kidnapped along with his fiancée, Lauren Sadler, by crazed hunter extraordinaire Danton Vachs. Every year he holds a contest where people can purchase the right to hunt down and kill a human being. This time, Collins is to be the hunted. Vachs uses Lauren as motivation for Collins to really fight to survive and thus provide the buyers with a truly exceptional hunt. Collins is turned loose on an uncharted island and four killers set out to find and kill him.
Two men face the consequences of gambling after playing with men beyond their league.