A cidade precisa de heróis. A escuridão instalou-se em Nova Iorque desde que Shredder colocou o seu punho de ferro em todo o lado.

O futuro é cruel até quatro improváveis irmãos se erguerem dos esgotos e descobrirem o seu destino como Tartarugas Ninja.

Estes heróis mutantes vão ter de trabalhar com a destemida repórter April O’Neil para salvar a cidade e travar os planos diabólicos de Shredder.

Leonardo, Raphael, Michaelangelo and Donatello must save New York City from the evil crime lord Shredder and his assistant, Baxter Stockman. The Turtles must fight foot soldiers, mice, and gangs and get help from their sensei Splinter, her friend April O'Neil, and her partner Casey Jones in an action-packed new series.

When the Teenage Mutant Ninja Turtles acquire Mutastones from Crys-Mu, the spirit of light, they acquire the ability to enhance themselves into Super Turtles for a duration of three minutes. Meanwhile, the evil Shredder and his minions Bebop and Rocksteady stumble upon the Dark Mutastone, which transforms them into Devil Shredder, Supermutant Bebop and Supermutant Rocksteady, respectively. But the Turtles have one more trick up their shells: all four of them can combine into their ultimate form—Turtle Saint.