Quatre tortugues mutants, en Donatello, en Michelangelo, en Leonardo i en Raphael, que, ajudades pel seu mestre, un ratolí mutant, lluitaran contra les accions de la banda de Shredder, conegut amb el nom de Tecnodrom, que intenten destrossar l'ordre i la pau de la ciutat, i alhora destruir les tortugues Ninja, que són els seus pitjors enemics.
Leonardo, Raphael, Michaelangelo and Donatello must save New York City from the evil crime lord Shredder and his assistant, Baxter Stockman. The Turtles must fight foot soldiers, mice, and gangs and get help from their sensei Splinter, her friend April O'Neil, and her partner Casey Jones in an action-packed new series.
When the Teenage Mutant Ninja Turtles acquire Mutastones from Crys-Mu, the spirit of light, they acquire the ability to enhance themselves into Super Turtles for a duration of three minutes. Meanwhile, the evil Shredder and his minions Bebop and Rocksteady stumble upon the Dark Mutastone, which transforms them into Devil Shredder, Supermutant Bebop and Supermutant Rocksteady, respectively. But the Turtles have one more trick up their shells: all four of them can combine into their ultimate form—Turtle Saint.