Doormat Wesley Gibson discovers that his recently murdered father - who Wesley never knew - belonged to a secret guild of assassins. After a leather-clad sexpot drafts Wesley into the society, he hones his innate killing skills and turns avenger.

A group of Iraq War veterans goes on the run from U.S. military forces while they try to clear their names after being framed for a crime they didn't commit. Along the way, Col. Hannibal Smith, Capt. H.M. ‘Howling Mad’ Murdock , Sgt. Bosco ‘B.A.’ Baracus, and Lt. Templeton ‘Faceman’ Peck help out various people they encounter.

NYPD Detective Sara Pezzini's main goal in life was to bring down Tommy Gallo, the hitman who killed her father, her best friend, and eventually her partner. While chasing down one of Gallo's thugs, she acquires the Witchblade, an enchanted armored glove once used by Joan of Arc that deflects bullets, extends into bladed weapons, produces visions, and neatly compacts itself into a bracelet.