When three women living on the edge of the American frontier are driven mad by harsh pioneer life, the task of saving them falls to the pious, independent-minded Mary Bee Cuddy. Transporting the women by covered wagon to Iowa, she soon realizes just how daunting the journey will be, and employs a low-life drifter, George Briggs, to join her. The unlikely pair and the three women head east, where a waiting minister and his wife have offered to take the women in. But the group first must traverse the harsh Nebraska Territories marked by stark beauty, psychological peril and constant threat.

When brash Texas border officer Mike Norton wrongfully kills and buries the friend and ranch hand of Pete Perkins, the latter is reminded of a promise he made to bury his friend, Melquiades Estrada, in his Mexican home town. He kidnaps Norton and exhumes Estrada's corpse, and the odd caravan sets out on horseback for Mexico.

A deeply religious black ex-con thwarts the suicide attempt of an asocial white college professor who tries to throw himself in front of an oncoming subway train, 'The Sunset Limited.' As the one attempts to connect on a rational, spiritual and emotional level, the other remains steadfast in his hard-earned despair. Locked in a philosophical debate, both passionately defend their personal credos and try to convert the other.

An aging cowboy must choose between his desire to remain free and the responsibilities of maintaining a family.