Max, en dygtig matematiker, som tror, at alt kan forklares ved hjælp af tal, står over for sit livs største opdagelse: at kunne forudsige, hvad der vil ske på aktiemarkederne. Der udbryder kaos, da både et Wall Street-firma og en religiøs sekt får øjnene op for Max' færdigheder, samtidigt med at han plages af hallucinationer, migræne og paranoia.

Drew (Scott Caan) must care for his father, a former professor who can now barely communicate due to Alzheimer. Depressed and struggling to make ends meet, an old buddy tries to get him to become a pusher. He gets further drawn in by a new and exciting girlfriend, Sarah (Mia Kirshner), who uses drugs.

With the help of her mother, family, friends, and fellow musicians, Aiyana Elliott reaches for her father, legendary cowboy troubadour, Ramblin' Jack Elliott. She explores who he is and how he got there, working back and forth between archival and contemporary footage. Born in 1932 in Brooklyn, busking through the South and West in the early 50s, a year with Woody Guthrie, six years flatpicking in Europe, a triumphant return to Greenwich Village in the early 60s, mentoring Bob Dylan, then life on the road, from gig to gig, singing and telling stories. A Grammy and the National Medal of Arts await Jack near the end of a long trail. What will Aiyana find for herself?