When Miley Stewart (aka pop-star Hannah Montana) gets too caught up in the superstar celebrity lifestyle, her dad decides it's time for a total change of scenery. But sweet niblets! Miley must trade in all the glitz and glamour of Hollywood for some ol' blue jeans on the family farm in Tennessee, and question if she can be both Miley Stewart and Hannah Montana.

職業殺手占美保寶(史泰龍 飾)與拍檔路易幹掉目標後，占美前往收錢，卻發現拍檔路易倒臥血泊之中死亡。華盛頓探員泰萊(成康 飾)來到新奧爾良調查拍檔被殺一案時，卻意外發現事件與路易被殺一案有關。殺手占美與警探泰萊原本黑白兩道勢不兩立，但二人的拍檔同樣被殺，令泰萊找上了占美協助調查，但占美拒絕跟警察合作，之後泰萊被伏襲中槍，神秘的占美終出手相救……正所謂「敵人的敵人就是朋友」，為了替死去的拍檔報仇，讓原本陌生的二人頓時惺惺相惜，誓要找出共同敵人。