Framed for crimes against the country, the G.I. Joe team is terminated by Presidential order. This forces the G.I. Joes into not only fighting their mortal enemy Cobra; they are forced to contend with threats from within the government that jeopardize their very existence.

Retired C.I.A. agent Frank Moses reunites his unlikely team of elite operatives for a global quest to track down a missing portable nuclear device.

Former race car driver Brent Magna is pitted against the clock. Desperately trying to save the life of his kidnapped wife, Brent commandeers a custom Ford Shelby GT500 Super Snake, taking it and its unwitting owner on a high-speed race against time, at the command of the mysterious villain holding his wife hostage.