Grindhouse combines Robert Rodriguez's Planet Terror, a horror comedy about a group of survivors who battle zombie-like creatures, and Quentin Tarantino's Death Proof, an action thriller about a murderous stuntman who kills young women with modified vehicles. It is presented as a double feature with fictitious exploitation trailers before each segment.
A high school swim champion with a troubled past enrolls in the U.S. Coast Guard's 'A' School, where legendary rescue swimmer, Ben Randall teaches him some hard lessons about loss, love, and self-sacrifice.
Katherine Morrissey, a former Christian missionary, lost her faith after the tragic deaths of her family. Now she applies her expertise to debunking religious phenomena. When a series of biblical plagues overrun a small town, Katherine arrives to prove that a supernatural force is not behind the occurrences, but soon finds that science cannot explain what is happening. Instead, she must regain her faith to combat the evil that waits in a Louisiana swamp.
FBI agent Neville Flynn boards a flight from Honolulu, Hawaii to Los Angeles, escorting a key witness to testify against a mob boss at an upcoming trial. An on-board assassin releases a crate full of hundreds of deadly venomous snakes in an attempt to eliminate the witness. Flynn and a host of frightened passengers and crew must band together to survive the slithery threat.
Las Vegas showroom magician Cris Johnson has a secret which torments him: he can see a few minutes into the future. Sick of the examinations he underwent as a child and the interest of the government and medical establishment in his power, he lies low under an assumed name in Vegas, performing cheap tricks and living off small-time gambling "winnings." But when a terrorist group threatens to detonate a nuclear device in Los Angeles, government agent Callie Ferris must use all her wiles to capture Cris and convince him to help her stop the cataclysm.
In 2007, Wright directed a fake trailer insert for Quentin Tarantino and Robert Rodriguez's Grindhouse, called "Don't", it was a plotless trailer that mocked horror clichés.