"Agente 47" narra la historia de un asesino de élite que ha sido genéticamente alterado para convertirse en una perfecta máquina de matar. Su objetivo es acabar con una gran corporación que planea desvelar los secretos de su organización secreta. Para ello, forma equipo con una joven.

John Prophet, a DNA-enhanced super-soldier, is placed into a cryogenic freeze for a future mission, only to awaken prematurely in the present. As he searches for a mission that does not exist, he must also find his humanity.

The story of a deadly CIA black ops assassin code-named the Scorpio, who specializes in regime changes, battles pirates, mercenaries and rogue agents.