20 years since their first adventure, Lloyd and Harry go on a road trip to find Harry's newly discovered daughter, who was given up for adoption.
After taking his dying father's advice, Hal dates only the embodiments of female physical perfection. But that all changes after Hal has an unexpected run-in with self-help guru Tony Robbins. Intrigued by Hal's shallowness, Robbins hypnotizes him into seeing the beauty that exists even in the least physically appealing women. Hal soon falls for Rosemary, but he doesn't realize that his gorgeous girlfriend is actually a 300-pound-not-so-hottie.
When best buds Rick and Fred begin to show signs of restlessness at home, their wives take a bold approach to revitalize their marriages, they grant the guys a 'hall pass'—one week of freedom to do whatever they want. At first, it seems like a dream come true, but they quickly discover that their expectations of the single life—and themselves—are completely and hilariously out of sync with reality.
Rhode Island State Trooper Charlie Baileygates has a multiple personality disorder. One personality is crazy and aggressive, while the other is more friendly and laid back. Both of these personalities fall in love with the same woman named Irene after Charlie loses his medication.
A white blood cell policeman, with the help of a cold pill, must stop a deadly virus from destroying the human they live in, Frank.
While trying to save their childhood orphanage, Moe, Larry and Curly inadvertently stumble into a murder plot and wind up starring in a reality TV show.
Eddie, the 40-year-old confirmed bachelor finally says "I do" to the beautiful and sexy Lila. But during their honeymoon in Mexico, the woman of his dreams turns out to be a total nightmare, and the guy who could never pull the trigger realizes he’s jumped the gun.
Boy meets girl; boy falls in love (and had wild, non-stop sex) with girl; boy loses girl... when they discover they are brother and sister! But when he learns that he's the victim of the ultimate case of mistaken identity, the lovesick young man -- whom everyone still thinks is after some taboo thrills -- must race across the country to stop her from marrying another man.
In Martha's Vineyard, Mass., conjoined twins Walt and Bob Tenor make the best of their handicap by being the fastest grill cooks in town. While outgoing Walt hopes to one day become a famous actor, shy Bob prefers to stay out of the spotlight. When a fading Hollywood actress, Cher, decides to get her show "Honey and the Beaze" cancelled, she hires Walt -- and his brotherly appendage -- as her costars. But their addition surprisingly achieves the opposite.
Liam, a likable 6th grader, writes to Santa asking him to prove that he's real. But Liam is dyslexic and accidentally sends his letter to Satan instead, who shows up at Liam's house, excited to have his first fanboy letter and wanting a little of Liam's soul.