Los Ángeles, año 2028. El Hotel Artemis es un hospital exclusivo para delincuentes, regentado por Jean Thomas (Jodie Foster) y ceñido a unas reglas muy estrictas. Cuando el centro es atacado, dará paso a una espiral de violencia difícil de contener.

South Beach bouncer Ray Sagona is on the brink of finding redemption and getting his family back. But when a drug-filled safe is stolen from the club he works at, Ray is blackmailed into finding it before the Miami PD narcotics bureau does. As his past and present collide in dangerous ways, Ray must survive an epic 36-hour odyssey across Miami Beach to retrieve the safe.

A sci-fi courtroom drama in which a robotic "companion doll" kills its owner and then shocks the world by claiming that she is not guilty and asking for a lawyer.