McCall races to find a woman kidnapped by a serial killer whose past crimes went undetected because the victims were from marginalized communities. Also, trouble arises for McCall when her vigilante activity puts her on Manhattan District Attorney Avery Grafton's radar.

Mel’s past military expertise proves critical when McCall is hired by District Attorney Grafton to find a sniper on a killing spree, seemingly selecting victims at random. Also, Delilah experiences PTSD when the sniper shootings cause her to relive the trauma of her friend’s fatal shooting.

McCall receives a desperate plea for help from her former CIA trainee, now a full-fledged agent, that leads her into a confrontation with Mason Quinn, the most dangerous enemy from her past in intelligence. In need of confidential information about the agent's latest assignment, McCall forms a tentative alliance with Carter Griffin, a by-the-book CIA handler.

The team helps an NYPD firefighter’s daughter when her father suddenly goes missing. Also, Aunt Vi and Delilah continue to cope after McCall’s abduction.

When a man claiming to have lost his memory wakes up behind a dumpster with a gun in his hand, McCall and the team follow a trail of clues to help uncover his whereabouts the night before.

When Fisk tasks McCall with tracking down an ex-MI6 agent in Paris with whom she had a past relationship, she must convince him to help her track down a crucial document that his friend was hiding. Also, Delilah faces discrimination at her new fashion internship.